要点记录：慢性牙周炎分级，HIV相关的牙周菌群，取样的点是确定唾液还是菌斑或者其他的部位。
检索词：PubMed（HIV periodontitis 16S）
1、检索日期
2024年1月17日
2、检索结果
16个结果
3、强相关论文
Oral microbiome in HIV-associated periodontitis.
Non-surgical periodontal debridement affects subgingival bacterial diversity in patients with HIV-1 and periodontitis.
Subgingival bacterial community profiles in HIV-infected Brazilian adults with chronic periodontitis.
Significant effect of HIV/HAART on oral microbiota using multivariate analysis.
Oral bacteriome of HIV-1-infected children from Rio de Janeiro, Brazil: Next-generation DNA sequencing analysis.
Beyond the effects of HIV infection and integrase inhibitors-based therapies on oral bacteriome - PubMed (nih.gov)
Oral microbiota in youth with perinatally acquired HIV infection - PubMed (nih.gov)
Periodontal pathogens in subgingival plaque of HIV-positive subjects with chronic periodontitis - PubMed (nih.gov)
Subgingival plaque microbiota in HIV positive patients - PubMed (nih.gov)
Oral and Gut Microbial Diversity and Immune Regulation in Patients with HIV on Antiretroviral Therapy - PubMed (nih.gov)
The Oral Bacterial Communities of Children with Well-Controlled HIV Infection and without HIV Infection - PubMed (nih.gov)
Relationship between the Oral and Vaginal Microbiota of South African Adolescents with High Prevalence of Bacterial Vaginosis - PubMed (nih.gov)
Alterations in the oral microbiome in HIV-infected participants after antiretroviral therapy administration are influenced by immune status - PubMed (nih.gov)
The diversity of periodontal spirochetes by 16S rRNA analysis - PubMed (nih.gov)
检索词：CNKI（HIV 牙周炎 ）
1、检索日期
2024年1月17日
2、检索结果
48个中文结果，61个外文期刊
3、强相关论文
HIV+牙周炎患者免疫状态和龈沟液中TNF-α与牙周临床指标的相关性研究
HIV+牙周炎患者龈沟液IL-6的检测分析
白细胞介素6在HIV感染牙周炎患者中的表达与作用
HIV感染和牙周病相关性的研究进展
HIV感染患者的口腔表征及研究进展
HIV感染者牙周炎的相关研究
HIV感染牙周炎患者口腔牙龈上皮中的朗格罕细胞减少和角朊细胞HLA-DR表达增加
HIV感染和牙周病
Immune markers and microbial factors are related with periodontitis severity in people with HIV.
“The effect of antiretroviral therapy (HAART) on the periodontal conditions of patients with HIV-infection: A systematic review and meta-analysis”.
A systematic review of four decades of prevalence of oral soft tissue infections and conditions among adult HIV patients in India.
In vitro Azole antifungals susceptibility of Candida spp. isolates from HIV-infected patients with periodontitis.
Association between BMI and periodontitis in women living with or at risk for HIV.
Correction to: Stage II and stage III periodontitis clinical burdens of HIV‑1 undergoing antiretroviral therapy
Stage II and stage III periodontitis clinical burdens of HIV-1 undergoing antiretroviral therapy.
Non-surgical periodontal debridement affects subgingival bacterial diversity in patients with HIV-1 and periodontitis.
Association of periodontitis with markers of immunologic and haemostatic state in people living with HIV
Periodontitis and cytomegalovirus associate with atherosclerosis among HIV patients after 5 years on ART.
Severe Necrotizing Periodontitis in HIV-Infected Patient: Case Report and Non-Surgical Treatment
Clinical efficacy of photodynamic therapy in the treatment of necrotizing ulcerative periodontitis among HIV seropositive patients: A randomized controlled clinical trial
PERIODONTAL THERAPY AFFECTS ORAL COLONIZATION OF CANDIDA SPP AND HIV INFECTION STATUS IN PATIENTS WITH PERIODONTITIS
HIV status does not worsen oral health outcomes
Gingival Recession and Localized Aggressive Periodontitis Among HIV-infected Children and Adolescents Receiving Antiretroviral Therapy.
Candida spp. Determination and Th1/Th2 Mixed Cytokine Profile in Oral Samples From HIV+ Patients With Chronic Periodontitis
Effects of non-surgical periodontal therapy on clinical and immunological profile and oral colonization of Candida spp in HIV-infected patients with chronic periodontitis.
Severe periodontitis is more common in HIV- infected patients
Periodontists’ perspective of HIV manifestations
Absence of cytomegalovirus in gingivitis and chronic periodontitis in HIV-1 patients in Northern Brazil.
Factors associated with dental caries, periodontitis and intra-oral lesions in individuals with HIV / AIDS
Relationship between human immunodeficiency virus (HIV-1) infection and chronic periodontitis.
Prevalence of Periodontitis and Soft Tissue Lesions among Human Immunodeficiency Virus-positive Patients on Antiretroviral Therapy in Raichur Taluk, Karnataka, India.
Analysis of IL-10 in HIV-1 patients with chronic periodontitis in northern Brazil
Oral microbiome in HIV-associated periodontitis
Impact of periodontal intervention on local inflammation, periodontitis, and HIV outcomes.
Lactoferrin levels in gingival crevicular fluid and saliva of HIV-infected patients with chronic periodontitis.
Lactoferrin levels in gingival crevicular fluid and saliva of HIVHIV ‐infected patients with chronic periodontitis
Prevalence and Determinants of Chronic periodontitis in HIV positive patients in Nigeria
Association of CD(+)4 T lymphocyte count and gingival crevicular fluid prostaglandin E2 with periodontal parameters in HIV-positive periodontitis patients].
Mast Cell Degranulation in the Chronic Periodontitis of Non−HIV-Infected and HIV-Infected Individuals Undergoing Highly Active Antiretroviral Therapy
Associations of periodontitis and oral manifestations with CD4 counts in human immunodeficiency virus-pregnant women in Thailand
Mast cells in periodontal disease of individuals with and without HIV undergoing highly active antiretroviral therapy.
Periodontal status of HIV infected patients with special reference to CD4 cell count in West Bengal, India
PDT in non-surgical treatment of periodontitis in HIV patients: a split-mouth, randomized clinical trial.
A Comparison of Chronic Periodontitis in HIV-Seropositive Subjects and the General Population in the Ga-Rankuwa Area, South Africa
Relationship between herpesviruses and periodontopathogens in patients with HIV and periodontitis.
Risk factors for periodontitis in HIV+ patients
Association of T CD4 lymphocyte levels and subgingival microbiota of chronic periodontitis in HIV-infected Brazilians under HAART
Periodontal pathogens in subgingival plaque of HIV-positive subjects with chronic periodontitis.
Differential diagnosis in dentistry. HIV-associated periodontitis.
检索词：CNKI（艾滋病 牙周炎 ）
1、检索日期
2024年1月17日
2、检索结果
1.24万个中文结果，189个外文期刊
3、强相关论文
从题目中分析，前10页200篇论文主体尚未发现研究艾滋病感染者的牙周炎情况的研究，由于无法遍历完全文章，故待后续精度该检索词下的文章。原因推测是，在牙周炎的文章中很多会提到艾滋病，所以命中比较多。
检索词：万方数据库（HIV 牙周炎）
1、检索日期
2024年1月17日
2、检索结果
47个结果
3、强相关论文
HIV+牙周炎患者龈沟液IL-6的检测分析 (wanfangdata.com.cn)
HIV+牙周炎患者免疫状态和龈沟液中TNF-α与牙周临床指标的相关性研究 (wanfangdata.com.cn)
HIV感染者牙周炎的相关研究 (wanfangdata.com.cn)
白细胞介素6在HIV感染牙周炎患者中的表达与作用 (wanfangdata.com.cn)
HIV感染牙周炎患者口腔牙龈上皮中的朗格罕细胞减少和角朊细胞HLA-DR表达增加 (wanfangdata.com.cn)
无症状期HIV感染者免疫状态与牙周指数的关系 (wanfangdata.com.cn)
牙周炎症可能会激活潜伏的HIV (wanfangdata.com.cn)
CD4计数和龈沟液PGE2与HIV+患者牙周炎的相关性研究 (wanfangdata.com.cn)
38例HIV/AIDS患者急性牙龈出血诊治体会 (wanfangdata.com.cn)
HIV感染和牙周病相关性的研究进展 (wanfangdata.com.cn)
以口腔损害为HIV／AIDS首诊症状24例分析 (wanfangdata.com.cn)
HIV感染相关牙周疾病研究情况 (wanfangdata.com.cn)
某省在押HIV感染者/AIDS患者口腔表征的流行现状及其影响因素分析 (wanfangdata.com.cn)
艾滋病口腔黏膜表现一例 (wanfangdata.com.cn)
AIDS患者唾液细菌多样性的研究 (wanfangdata.com.cn)
艾滋病病人牙周健康状况调查及干预措施研究 (wanfangdata.com.cn)
Clinical and microbiological profiles of human immunodeficiency virus (HIV)-seropositive Brazilians undergoing highly active antiretroviral therapy and HIV-seronegative Brazilians with chronic periodontitis. (wanfangdata.com.cn)
Periodontitis and Cytokine Patterns in HIV Positive Patients. (wanfangdata.com.cn)
Risk factors for periodontitis in HIV patients. (wanfangdata.com.cn)
Subgingival plaque microbiota in HIV positive patients. (wanfangdata.com.cn)
High numbers of T cells in gingiva from patients with human immunodeficiency virus (HIV) infection. (wanfangdata.com.cn)
Oral manifestations in HIV infection: fungal and bacterial infections, Kaposi’s sarcoma. (wanfangdata.com.cn)
IgG subclass specific antibody response to periodontopathic organisms in HIV-positive patients. (wanfangdata.com.cn)
Long-term results of supportive periodontal therapy (SPT) in HIV-seropositive and HIV-seronegative patients. (wanfangdata.com.cn)
Association of T CD4 lymphocyte levels and subgingival microbiota of chronic periodontitis in HIV-infected Brazilians under HAART. (wanfangdata.com.cn)
Herpesviruses in HIV-periodontitis. (wanfangdata.com.cn)
Association of T CD4 lymphocyte levels and chronic periodontitis in HIV-infected brazilian patients undergoing highly active anti-retroviral therapy: clinical results. (wanfangdata.com.cn)
Specific microbial colonizations in the periodontal sites of HIV-infected subjects. (wanfangdata.com.cn)
The gingival plasma cell infiltrate in HIV-positive patients with periodontitis is disorganized. (wanfangdata.com.cn)
The associations between gingival crevice fluid matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1 and periodontitis in human immunodeficiency virus-positive patients. (wanfangdata.com.cn)
A TEM/SEM study of the microbial plaque overlying the necrotic gingival papillae of HIV-seropositive, necrotizing ulcerative periodontitis. (wanfangdata.com.cn)
阅读记录
HIV+牙周炎患者的牙周炎症状态与免疫状态有关
HIV+牙周炎患者的牙周炎症程度与CD4+T淋巴细胞计数有关, 其龈沟液中IL-6水平与牙周临床指标有关
艾滋病即获得性免疫缺陷综合征 (acquiredimmunodeficiency syndrome, AIDS)，是由人类免疫缺陷病毒 (human immunodeficiency virus, HIV) 感染所导致的以CD4 细胞缺损和功能障碍为中心的严重免疫缺陷。HIV感染者口腔中的病损最常见的是普通的牙周病。HIV阳性者的免疫状态会影响牙周病的发生、发展，HIV感染可改变牙周微生物学组成。
牙周慢性感染可能会导致HIV潜伏在感染细胞中的病毒复活及播散，对公众的人身健康造成影响—研究依据1
线状牙龈红斑、坏死溃疡性牙龈炎、坏死溃疡性牙周炎是和HIV感染有着密切相关的牙周病损形式，随着高效抗病毒治疗的应用，这种急性牙周病损形式发病率明显减低，而慢性牙龈炎和慢性牙周炎更为常见。----研究依据2
思维灵感
1、缺乏HIV+性患者口腔菌群的差异研究-2024年1月18日
2、HIV+患者免疫系统受到抑制，会导致牙周菌群和宿主口腔免疫之间的平衡被打破。自然而然，HIV+患者口腔内菌群会和无HIV感染人群的牙周炎存在差异。那么一些机会致病菌以及明确致病菌的丰富度在HIV+患者体内有没有较大程度地改变？这现在是未知的。
3、研究证明，HIV+患者口腔的牙周病发病率远高于无HIV感染的人群。口腔菌群有没有可能是导致其口腔发病率高的原因？
4、菌群代谢物与宿主的免疫调节之间存在明显的相关关系，那么优势致病菌以及机会致病菌的代谢物可能是导致HIV+患者牙周炎发病率高的重要原因？到底是不是这么回事儿，亟需我们的研究来证明。
5、牙周慢性感染可能会导致HIV潜伏在感染细胞中的病毒复活及播散，对公众的人身健康造成影响，并且重庆地区HIV感染率在全国排第三位，相对其他地区感染率较高。研究口腔微生物的代谢物对HIV+人群口腔疾病的影响可以从临床降低HIV+人群口腔疾病的发生发展状态。
6、研究意义：1、降低HIV+人群慢性牙周炎的发病率。2、
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